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~<h5>NSAIDs like aspirin act by inhibiting the enzyme cyclooxygenase (COX). One form of COX, COX&#8208;1, is related mainly to the stomach mucous and kidney function effects. While desirable to develop a drug that inhibits COX&#8208;2 without inhibiting COX&#8208;1, it appears that inhibiting COX&#8208;2 stimulates the production of a protein called tissue factor (TF) which initiates blood clotting which in turn can trigger heart attacks and strokes. </h5>
