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~<h5>Acetaminophen (Tylenol&#174;) is not considered an NSAID. It appears to bind to COX&#8208;2 selectively but for some reason its anti&#8208;inflammatory activity is reduced compared to NSAIDs. A metabolic product of acetaminophen is an analog of anandamide and may interfere with the endogenous cannabinoid system. The endogenous cannabinoid system is the biochemical system that mediates the effects of marijuana. Acetaminophen is toxic in high doses with overdoses causing liver failure. </h5>
